• COVER: The Resurrection of John McCain — Rising from the ashes again, John McCain may be the GOP's only hope for winning the White House in November. But he still has to convince Republicans that he's one of them
• SCIENCE: Scientist Creates Life — Almost--Craig Venter has built the first man-made genome. Soon those genes may cause a cell to come alive. This tiny organism will be Venter's own — and that's just the start
• BUSINESS: Can the World Stop The Slide? — The U.S. is heading into its first recession in a truly globalized world. Here's what to expect--and why it will be different this time
• PEOPLE: 10 Questions for John Grisham — This former lawyer—and lawmaker—found his greatest success writing legal thrillers like The Client and A Time to Kill. His latest book, The Appeal, is out Jan. 29. John Grisham will now take your questions

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